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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF12
All Species:
14.24
Human Site:
S1457
Identified Species:
34.81
UniProt:
Q9NZN5
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZN5
NP_056128.1
1544
173232
S1457
S
T
H
Q
Q
Q
H
S
P
Q
N
T
H
S
D
Chimpanzee
Pan troglodytes
XP_001166830
1544
173242
S1457
S
T
H
Q
Q
Q
H
S
P
Q
N
T
H
S
D
Rhesus Macaque
Macaca mulatta
XP_001116843
1562
172109
G1443
P
R
P
Q
L
Q
G
G
N
G
D
P
R
R
L
Dog
Lupus familis
XP_536546
1708
190894
S1475
C
A
R
P
Q
Q
H
S
P
Q
H
A
H
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4H2
1543
172304
S1457
S
S
H
Q
Q
Q
H
S
P
Q
N
V
H
P
E
Rat
Rattus norvegicus
Q9ES67
1527
168515
I1434
V
D
V
I
F
H
T
I
E
Q
L
T
I
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505606
1628
182548
F1513
C
A
D
E
Q
E
R
F
C
Q
D
A
Q
P
D
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001082763
1450
164220
S1365
S
S
T
D
D
D
L
S
A
S
H
Y
S
N
Q
Zebra Danio
Brachydanio rerio
XP_001920310
1422
158610
T1338
A
G
S
G
E
S
S
T
D
D
D
A
Q
G
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393610
1768
197046
R1640
A
T
G
C
P
S
P
R
M
H
L
H
P
Q
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
30.8
83
N.A.
89.2
30.5
N.A.
75.6
N.A.
57.8
46.3
N.A.
N.A.
22.9
N.A.
N.A.
Protein Similarity:
100
99.9
48.9
84.8
N.A.
92.9
48
N.A.
82.3
N.A.
72.2
62.3
N.A.
N.A.
41.4
N.A.
N.A.
P-Site Identity:
100
100
13.3
60
N.A.
73.3
13.3
N.A.
20
N.A.
13.3
0
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
100
20
66.6
N.A.
86.6
13.3
N.A.
40
N.A.
33.3
26.6
N.A.
N.A.
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
20
0
0
0
0
0
0
10
0
0
30
0
0
0
% A
% Cys:
20
0
0
10
0
0
0
0
10
0
0
0
0
0
10
% C
% Asp:
0
10
10
10
10
10
0
0
10
10
30
0
0
0
40
% D
% Glu:
0
0
0
10
10
10
0
0
10
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
10
0
0
10
10
0
10
0
0
0
10
0
% G
% His:
0
0
30
0
0
10
40
0
0
10
20
10
40
0
0
% H
% Ile:
0
0
0
10
0
0
0
10
0
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% K
% Leu:
0
0
0
0
10
0
10
0
0
0
20
0
0
0
20
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
30
0
0
10
0
% N
% Pro:
10
0
10
10
10
0
10
0
40
0
0
10
10
20
0
% P
% Gln:
0
0
0
40
50
50
0
0
0
60
0
0
20
10
20
% Q
% Arg:
0
10
10
0
0
0
10
10
0
0
0
0
10
10
0
% R
% Ser:
40
20
10
0
0
20
10
50
0
10
0
0
10
30
0
% S
% Thr:
0
30
10
0
0
0
10
10
0
0
0
30
0
0
0
% T
% Val:
10
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _